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Heterosynaptic eLTD happens at synapses adjacent to the stimulated synapses. By way of example, stimulation of Schaffer collaterals in hippocampal CA1 causes a persistent decrease in GABAergic inhibition of CA1 pyramidal neurons (106). The system of eLTD at hippocampal inhibitory synapses appears to demand inhibition of adenylyl cyclase and also th